The Zetasizer range provides high quality, stability indicating data for biological drug molecules in a short time frame, enabling this measurement to be implemented throughout the development pipeline.
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Factors affecting therapeutic efficacy and immunogenicity therefore need to be monitored throughout the development pipeline especially at early stages to de-risk the biological drug molecule and limit late-stage failures. Instabilities mainly result in denaturation and aggregation of the molecule through which they can lose their biological function, elicit an immune response and consequently limit its therapeutic viability. Variations in molecule concentration, external temperature, level of agitation and time all impact the stability of biological molecules. The breadth of applications covered by Zetasizer systems, coupled with tens of thousands of scientific citations, have earned these instruments a central space in many scientific faculties. The Zetasizer is an essential analytical tool for many academic laboratories worldwide, finding use in all applications where particle or molecular size and zeta potential analysis is required.
Malvern zetasizer pro pro#
The Malvern Panalytical Zetasizer Pro can be used in many industry applications, including: The optional MPT-3 Auto titrator enables study of the effect of changes in pHĪ range of disposable and reusable cells are available to optimize the measurement in terms of sample volume and concentration
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Also includes polarization filters for DDLS measurements Optical filter wheel with fluorescence filter to allow measurement of fluorescent samples without impairing overall system sensitivity.
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Malvern zetasizer pro how to#
ZS Xplorer software suite for simple and flexible method set-up and data analysisĪdaptive Correlation for faster, more reproducible sizing measurements with less sample preparationĭeep Learning empowered data quality system for assessment of any size data quality issues, with clear advice on how to improve results M3-PALS with Constant Current Mode for zeta potential and electrophoretic mobility measurements Non-Invasive Back-Scatter (NIBS) optics for versatile, high sensitivity, particle and molecular size measurements Even novice users will produce the highest-quality measurements, thanks to the intuitive interface and the deep learning empowered data quality advice system that highlights issues and provides advice on how to overcome them.ĭynamic Light Scattering (DLS) measures particle and molecule size, from below 1 nm to 10 µmĮlectrophoretic Light Scattering (ELS) measures the zeta potential of particles and molecules, indicating sample stability and/or propensity to aggregate